0000050404 00000 n [7] These infectious diseases, two of which are sexually transmitted, affect tens of millions of Americans and hundreds of millions of people worldwide every year. Each side of the mark must be -. The companys promotion agreement with Alliant Pharmaceuticals, which commenced in 2005, was terminated May 2007. Lindane is registered for use in 50 countries, with restricted-use status in 33 of these countries. Camphor benzalkonium methosulfate. In the 1940s, lindane was registered with the U.S. Department of Agriculture (USDA), and in 1951 it was approved by the U.S. Food and Drug Administration (FDA) for medical use in the treatment of scabies, head lice and pubic lice (crabs). The substance is very toxic to aquatic organisms. [7] [17] When used properly, lindane medications are safe and effective for the diseases they are approved. Nausea. 0000005726 00000 n (1) On single packagings or combination packagings where each single package or each inner packaging of combination packagings has: (i) A net quantity of 5 L (1.3 gallons) or less for liquids; or, (ii) A net mass of 5 kg (11 pounds) or less for solids. [18], Canadas Pest Management Regulatory Agency phased out of all agricultural uses of lindane between 2000 and 2005 due to concerns of chronic occupational exposure and risks to workers during seed treatment and planting. LINDANE A REVIEW OF TOXICITY AND Your browser does not support JavaScript. xref This produces toxic and corrosive fumes including chlorine (see ICSC 0126), hydrogen chloride (see ICSC 0163) and phosgene (see ICSC 0007). Gives off irritating or toxic fumes (or gases) in a fire. (c) A transport vehicle or freight container that contains a package subject to the marking requirements of paragraph (a) or (b) of this section must be marked with the MARINE POLLUTANT mark. Cyanobacteria are able to tolerate, and even metabolize, moderate doses of organochlorine pesticides, such as lindane (γ-hexachlorocyclohexane), one of the most persistent and widely used in recent decades. WebLindane is released into the environment during and after agricultural application through volatilization into the atmosphere (estimated at 12-30%), where it has long-range transport potential and can be deposited by rainfall. "[14], The most common side effects associated with topical use of lindane medications are nonserious reactions of the skin, including burning, itching, dryness and rash. Code of Federal Regulations Title 49. United Nations Environment Programme - POPs Lindane Exposure could cause death. [24] The Joint Committee on Pesticide Residues (JMPR) of The World Health Organization and Food and Agricultural Organization of the United Nations similarly concluded in 2004 that In the absence of genotoxicity and on the basis of the weight of the evidence from the studies of carcinogenicity, JMPR has concluded that lindane is not likely to pose a carcinogenic risk to humans.[21], The production and use of lindane in agricultural (both of which have declined significantly in the last 20 years) are the primary causes of environmental contamination,[25] and levels of lindane in the environment have waned in the U.S. from 1986 through 2003, consistent with decreasing agricultural usage patterns.